Daptomycin versus Vancomycin in a Methicillin - Resistant 2 Staphylococcus Aureus Endophthalmitis Rabbit Model : 3 Bactericidal Effect , Safety and Ocular Pharmacokinetics
نویسندگان
چکیده
1 DAPTOMYCIN VERSUS VANCOMYCIN IN A METHICILLIN-RESISTANT 2 STAPHYLOCOCCUS AUREUS ENDOPHTHALMITIS RABBIT MODEL: 3 BACTERICIDAL EFFECT, SAFETY AND OCULAR PHARMACOKINETICS 4 5 Running title: Intravitreal daptomycin and endophthalmitis 6 7 8 9 10 Sophie Lefèvre 2 , Maher Saleh , Luc Marcellin, Audrey Subilia, Tristan Bourcier , 11 Gilles Prévost, François Jehl 2 12 13 1 Institute of bacteriology, University of Strasbourg, 3 rue koeberlé, Strasbourg, France. 14 2 Department of Bacteriology, University Hospital of Strasbourg, Strasbourg, France 15 3 Department of Ophthalmology, University Hospital of Strasbourg, Strasbourg, France 16 4 Department of Pathology, University Hospital of Strasbourg, Strasbourg, France 17 18 19 20 21 22 *Corresponding author: Sophie Lefèvre, Institut de bactériologie, Université de Strasbourg, 23 3 rue Koeberlé, 67000 Strasbourg, France. Telephone number: + 33 3 68 85 37 53, Fax 24 number: + 33 3 69 55 16 98. E-mail address: [email protected]. 25 26 Copyright © 2012, American Society for Microbiology. All Rights Reserved. Antimicrob. Agents Chemother. doi:10.1128/AAC.05745-11 AAC Accepts, published online ahead of print on 27 February 2012
منابع مشابه
Daptomycin versus vancomycin in a methicillin-resistant Staphylococcus aureus endophthalmitis rabbit model: bactericidal effect, safety, and ocular pharmacokinetics.
Staphylococcus aureus is a frequent cause of acute endophthalmitis, and infection with this virulent bacterium is often associated with a poor visual outcome. In this study, we investigated the bactericidal efficacy and the safety of intravitreal daptomycin (DAP), a lipopeptide antibiotic with broad-spectrum activity against Gram-positive bacteria, compared with those of intravitreal vancomycin...
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